Area under the curve as a tool to measure kinetics of tumor growth in experimental animals

Measurement of tumor diameters or tumor volumes has been traditionally used to quantitate and compare tumor growth curves in mice and rats. Here, we describe the use of area under the curve (AUC) as an alternative method to do the same. This single numerical value (a) is easy to obtain for individual curves, (b) reflects the entire tumor growth curve through a single number, (c) can be easily modified to obtain data for defined sections of the growth curve (for example, to determine stable disease), and (d) allows easier comparisons between groups. Using tumor growth data from a large number of mice challenged with live tumor cells, we demonstrate the utility of this tool over the conventional methods for these purposes. (C) 2012 Elsevier B.V. All rights reserved.