Copper(I)-Taniaphos Catalyzed Enantiodivergent Hydroboration of Bicyclic Alkenes

In this study, highly enantioselective copper(I)-catalyzed hydroboration of bicyclic alkenes is reported. Using a copper-taniaphos complex, excellent enantioselectivities up to >99% ee were obtained for bicyclic alkenes including oxa- and azabicyclic alkenes. Furthermore, copper-catalyzed enantiodivergent hydroboration methods with the same chiral ligand-copper precursors were developed using different boron sources based on alternative mechanistic pathways.