期刊
JOURNAL OF IMMUNOLOGICAL METHODS
卷 338, 期 1-2, 页码 79-84出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jim.2008.07.015
关键词
lupus; B cells; immunoglobulins; peptide
资金
- NIH
- Cancer Research Institute
Autoreactive B cells play a central role in systemic lupus erythematosus (SLE). Characterization of DNA-reactive B cells in the blood of lupus patients has been limited by the low frequency of the population. Using a tetrameric configuration of a peptide mimetope of DNA, we identified peptide-reactive B cells in peripheral blood. Antibodies derived from these B cells bound to peptide and were largely cross-reactive to dsDNA. This methodology enables us to track the development of autoreactive B cells, which recognize peptide and dsDNA, in individual patients with SLE and permits the isolation of autoreactive B cells for further characterization. (C) 2008 Elsevier B.V. All rights reserved.
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