期刊
ORGANIC LETTERS
卷 17, 期 7, 页码 1684-1687出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00447
关键词
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资金
- National Science Foundation of China [21202093, 21472112]
- Program for New Century Excellent Talents in University [NCET-13-0346]
- Shandong Science Fund for Distinguished Young Scholars [JQ201404]
The first catalytic asymmetric cross-dehydrogenative coupling of cyclic carbamates and terminal alkynes has been established. The reaction features high enantiocontrol and excellent functional group tolerance and displays a wide range of structurally and electronically diverse carbamates as well as terminal alkynes. N-Acyl hemiaminals were identified as the reactive intermediates through preliminary control experiments. Employing readily removable carbamates as substrates rather than traditionally adopted N-aryl amines allows applications in complex molecule synthesis and therefore advances the CH functionalization strategy to a synthetically useful level.
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