期刊
ORGANIC LETTERS
卷 17, 期 15, 页码 3888-3891出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01872
关键词
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资金
- MEXT
- AMED, Japan
- JSPS KAKENHI [26560443, 26350971]
- Noguchi Institute
- Takeda Science Foundation
- Uehara Memorial Foundation
- Kurata Memorial Hitachi Science and Technology Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [26350971, 26560443] Funding Source: KAKEN
A novel synthetic method for v-coelenterazine (v-CTZ), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-coupling reactions and ring-closing metathesis (RCM). A newly synthesized C2-modified trifluoromethyl analog cf3-v-CTZ showed slightly more red-shifted luminescence than v-CTZ when it was used as a substrate for Renilla luciferases.
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