Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

Background:We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition.Objectives:To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance.Method:Twenty-eight obese but otherwise healthy adults (BMI: 33.30.6kg/m(2)) were randomized to take a single 75mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1h later.Results:Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P=0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r=-0.47, P=0.01). A single dose of resveratrol (75mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation.Conclusion:Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.