期刊
JOURNAL OF HYPERTENSION
卷 30, 期 1, 页码 210-216出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e32834e1e2e
关键词
combination therapy; felodipine; hypertension; oxidative stress; sexual dysfunction
资金
- Specific Project of Technological Research and Development in Gansu Province of China [0709TCYA068]
Objective To evaluate the impact of felodipine with irbesartan on sexual function compared with felodipine with metoprolol in hypertensive women. Methods This was a prospective, randomized, parallel, active-controlled, open-label study (ClinicalTrials.org: NCT01238705) in 160 women (18-60 years) with mild or moderate hypertension, randomized to a once-daily treatment with felodipine combined with irbesartan or metoprolol for 48 weeks. Patients' sexual function was evaluated using a female sexual function index (FSFI) questionnaire at baseline and after 24 and 48 weeks of therapy. Levels of serum estradiol, testosterone, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) were measured. Results The two combination regimens were similarly effective in lowering blood pressure. After 48 weeks, in felodipine-irbesartan group, total scores of FSFI improved (P<0.001). Items showing improvement in scores corresponded to desire, arousal and orgasm (P<0.001; P=0.002; P=0.049, respectively). Levels of estradiol increased under treatment with felodipine-irbesartan (P=0.003) and decreased under felodipine-metoprolol treatment (P<0.001). The concentration of testosterone declined after felodipine-irbesartan therapy (P<0.001) and increased under felodipine-metoprolol treatment (P<0.001). In the felodipine-irbesartan group, decreases of 8-OHdG, 4-HNE (P<0.001) and MDA (P<0.001) were observed. The felodipine-irbesartan combination resulted in less oxidative stress. The differences in changes in 8-OHdG, 4-HNE and MDA between the two groups were significant (P<0.05). Conclusion These results suggested that the felodipine-irbesartan combination regimen improved sexual function in hypertensive women, whereas felodipine-metoprolol regiment did not. The reason for the different influence of these two combination therapy on female sexual function might be their different impacts on oxidative stress and hormone levels. J Hypertens 30: 210-216 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据