期刊
ORGANIC LETTERS
卷 17, 期 9, 页码 2218-2221出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00816
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资金
- National Science Foundation [1361604]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1361604, 1541685] Funding Source: National Science Foundation
A concise synthesis (under 10 steps) of the stereotetrad core of the briarane diterpenoids is reported. This approach harnesses the unique reactivity of salicylate ester derived 2,5-cyclohexadienones to quickly build complexity. In particular, a highly diastereoselective acetylide conjugate addition/beta-ketoester alkylation sequence was used to set the relative configuration of the C1 (quaternary) and C10 (tertiary) vicinal stereocenters. The sterochemical outcome of the beta-ketoester alkylation appears to be governed by torsional steering in the transition state.
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