期刊
JOURNAL OF HYPERTENSION
卷 28, 期 5, 页码 979-984出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0b013e328336ed9a
关键词
arterial stiffness; autonomic nervous system; blood pressure; left ventricular function; pulse wave velocity; sympathetic nervous system
资金
- Polish Ministry of Science (Ministerstwo Nauki i Szkolnictwa Wyzszego) [2P05B 178 29]
- European Union [LSHM-CT-2006-037093]
- Foundation for Polish Science [TEAM/2008-2/5, MISTRZ 8/2008]
- National Institutes of Health (NIH) [HL61560, R03 TW0 1148]
- Ministry of Health of the Czech Republic [NS 100/98]
Objective Carotid-femoral pulse wave velocity (PWV) has been shown to be a powerful predictor of cardiovascular morbidity and mortality. Sympathetic neural mechanisms may have a stiffening influence on arterial mechanical properties. The relationship between direct measures of sympathetic traffic and PWV in healthy humans has not been previously studied. We, therefore, tested the hypothesis that PWV is independently linked to muscle sympathetic nerve activity (MSNA) in normal individuals. Methods We measured MSNA (microneurography), PWV (Complior device), heart rate and blood pressure in 25 healthy male participants (mean age 43 +/- 10 years). Results PWV correlated significantly with age (r=0.63, P<0.001), SBP (r=0.43, P<0.05) and MSNA (r=0.43, P<0.05) but not with BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or DBP. Robust multiple linear regression analysis revealed that only age and MSNA were linked independently to PWV (r(2)=0.62, P<0.001), explaining 39 and 25% of its variance, respectively. After adjustment of PWV for age and SBP, we further divided individuals into 'excessive' PWV (i.e. higher than expected from age and SBP) and 'optimal' PWV (i.e. lower than expected). BMI and blood pressure were similar in both subgroups. Individuals with excessive PWV had significantly greater MSNA than individuals with optimal PWV (30 +/- 10 vs. 18 +/- 11 bursts/min, P=0.01). Conclusion This study provides the first evidence that PWV is linked to MSNA in normal humans. The relationship between MSNA and PWV is independent of age, BMI, waist circumference, waist-to-hip ratio, heart rate, pulse pressure or blood pressure. J Hypertens 28:979-984 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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