期刊
ORGANIC LETTERS
卷 17, 期 10, 页码 2408-2411出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00919
关键词
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资金
- University of South Carolina
- National Science Foundation CAREER Award [CHE-1055616]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1055616] Funding Source: National Science Foundation
The silylation-based kinetic resolution of trans 2-arylcyclohexanols was accomplished by employing a triaryl silyl chloride as the derivatizing reagent with a commercially available isothiourea catalyst. The methodology is selective for the trans diastereomer over the cis, which provides an opportunity to selectively derivatize one stereoisomer out of a mixture of four. By employing this technology, a facile, convenient method to form a highly enantiomerically enriched silylated alcohol was accomplished through a one-pot reduction-silylation sequence that started with a 2-aryl-substituted ketone.
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