期刊
ORGANIC LETTERS
卷 17, 期 18, 页码 4542-4545出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02256
关键词
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资金
- NSF [CHE-1454845]
- American Chemical Society
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1454845] Funding Source: National Science Foundation
An oxidative formation of 1,4,2-oxathiazoles from readily available thiohydroximic acids is reported. A variety of alkyl, aryl, and heteroaryl substituents are well tolerated for both the thiohydroximic acid and activating fragments, and the reaction has been demonstrated on gram-scale. This reaction represents the only method currently available to prepare a diverse set of oxathiazoles and expands the chemistry of C-H oxidation via appended N-OH functional groups. Finally, we also demonstrate the rapid preparation of a 1,4,2-oxathiazole analog of an anticancer lead molecule.
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