Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications

The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted beta(2,3)-diarylamino acid and L-alanine are reported. Depending on the stereochemistry of the beta amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.