期刊
ORGANIC LETTERS
卷 17, 期 11, 页码 2820-2823出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01242
关键词
-
资金
- National Natural Science Foundation of China [21272085, 21472056]
A highly efficient multicomponent domino protocol has been developed for the synthesis of 5-phenyl-[1,2,3]triazolo[1,5-c]quinazolines from simple and readily available (E)-1-bromo-2-(2-nitrovinyl)benzenes, aldehydes, and sodium azide. This elegant domino process involved consecutive [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cyclization, and oxidation sequences. Notably, sodium azide acted as a dual nitrogen source in the construction of this novel fused N-heterocycle.
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