Synthesis and Evaluation of 5,5′-Bitetralone-Based Chiral Phosphoric Acids

A new type of phosphoric acid bearing a 5,5'-bitetralone scaffold was synthesized from BINOL and was shown to be a highly effective catalyst as illustrated in the asymmetric transfer hydrogenation of 2-phenylquinoline and the Friedel Crafts reaction of 2,2,2-trifluoroacetophenone.