4.8 Article

DABCO-Mediated [4+4]-Domino Annulation: Access to Functionalized Eight-Membered Cyclic Ethers

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ORGANIC LETTERS
卷 17, 期 19, 页码 4914-4917

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02498

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资金

  1. National Natural Science Foundation of China [20972076, 21172115, 21472097]
  2. Natural Science Foundation of Tianjin [15JCYBJC20000]
  3. Research Fund for the Doctoral Program of Higher Education of China [20120031110002]

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DABCO-mediated [4 + 4] domino annulation reactions of ynones and alpha-cyano-alpha,beta-unsaturated ketones were discovered. The domino process affords an alternative route to eight-membered cyclic ethers in good yields under mild conditions.

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