期刊
ORGANIC LETTERS
卷 17, 期 24, 页码 6238-6241出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03227
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资金
- National Natural Sciences Foundation of China (NNSFC) [81303209]
- China Postdoctoral Science Foundation (CPSF) [2014M562291]
- Sichuan Science and Technology Basic Research Program [2012JYZ005]
An architecturally complex spiroketal diterpenoid, leonuketal (1), was isolated from the aerial parts of the plant Leonurus japonicus. This compound possessed an unprecedented tetracyclic skeleton that comprised a bridged spiroketal moiety fused with a ketal-gamma-lactone unit. The structure and absolute configuration were determined by spectroscopic analyses, a modified Moshers method, and ECD (electronic circular dichroism) calculations. Leonuketal (1) showed significant vasorelaxant activity against KCl-induced contraction of rat aorta, with the EC50 value of 2.32 mu M.
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