Arboridinine, a Pentacyclic Ind le Alkaloid with a New Cage Carbon-Nitrogen Skeleton Derived from a Pericine Precursor

A new monoterpene indole alkaloid characterized by an unprecedented pentacyclic cage skeleton, arboridinine (1), was isolated from a Malaysian Kopsia species. The structure and absolute configuration of the alkaloid were determined based on NMR, MS, and X-ray diffraction analysis. A possible biogenetic pathway from a pericine precursor is presented.