期刊
ORGANIC LETTERS
卷 18, 期 1, 页码 4-7出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02839
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
An efficient asymmetric total synthesis of (S)-baclofen was accomplished via a one-pot operation from commercially available materials using sequential reactions, such as aldol condensation of acetaldehyde, diphenylprolinol silyl ether mediated asymmetric Michael reaction of nitromethane, Kraus-Pinnick oxidation, and Raney Ni reduction. Highly enantioenriched baclofen was obtained in one pot with a good yield over four reactions.
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