期刊
ORGANIC LETTERS
卷 17, 期 18, 页码 4514-4517出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02208
关键词
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资金
- UCSB
- Amgen
- NIH Shared Instrumentation grant (SIG) [1S10OD012077-01A1]
The first example of a general asymmetric nitrosocarbonyl hetero-ene reaction is described. The procedure uses a copper-catalyzed aerobic oxidation of a commercially available chiral nitrosocarbonyl precursor (EleNOr) and is operationally simple. The transformation is both high yielding and highly diastereoselective for a range of silyl enol ether derivatives. A variety of synthetically useful postfunctionalization reactions are presented along with a mechanistic rationale that can be used as a predictive model for future asymmetric reactions with nitrosocarbonyl intermediates.
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