Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa

Two new alkaloids flueggether A (1) and virosinine A (2), Were isolated from Chinese Medicinal plant, Flueggea virosa. Their Structures were assigned via spectroscopic methods with the absolute configurations of 1 and 2 Being established by X-ray diffraction analysis and calculated electronic circular dichroism data, respectively. Compound 1 represents the first example with an ether bridge of Securinega alkaloid oligomers, and 2 bears a new heterocyclic backbone. Both alkaloids showed mild in vitro anti-HIV activity.