期刊
ORGANIC LETTERS
卷 17, 期 18, 页码 4640-4643出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02398
关键词
-
资金
- DST-India [IFA12-CH-36]
- CSIR
The dual role of the bicyclic amidine base 1,8-diazabicydo[5.4.0]undec-7-ene (DBU) was demonstrated in a synthesis of terminal aryl- and styryl-acetylenes. Mechanistically, a tandem process involving elimination/Umpolung/protonation occurs in a single step to generate terminal aryland styryl-acetylenes from geminal dibromoalkenes. The key to the success of this transformation lies in the organobase-mediated generation of the acetylide from the 1-bromoalkynes at room temperature. The unique characteristics of DBU as an inherently safer reagent make it an attractive alternative to previous systems wherein required pyrophoric reagents and nonambient temperatures remain unsolved issues. The procedure does not work for the synthesis of alkyl-acetylenes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据