期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 29, 页码 7993-8000出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00815h
关键词
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资金
- National Natural Science Foundation of China [21372002, 21232007]
- Open Foundation of Jiangsu Key Laboratory [K201314]
- PAPD
- Qing Lan Project of Jiangsu Province
- Undergraduate Students Project of Jiangsu Normal University
A chiral phosphoric acid-catalyzed asymmetric reaction of 2-indolylmethanols with 3-alkylindoles has been established, which constructed a biologically important 2,2'-bisindolylmethane scaffold in high yields and good enantioselectivities (up to 98% yield, 94 : 6 er). This protocol not only provides an efficient method for constructing a 2,2'-bisindolylmethane framework in an enantioselective form, but also promotes the development of 2-indolylmethanol-involved catalytic asymmetric transformations.
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