期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 8, 页码 2247-2250出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02602k
关键词
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资金
- Fundamental Research Funds for the Central Universities [WK2060190041]
2-Amino-3-cyano-4H-chromenes show great potential as novel anticancer agents. Here we report a quinine-catalyzed highly enantioselective formal 4 + 2 cycloaddition of ortho-quinone methides and malononitrile, providing a unique approach to 4-arylvinyl, 4-aryl and 4-vinyl 2-amino-3-cyano-4H-chromenes with excellent yields and enantioselectivities. Moreover, this reaction can be performed in up to 6 mmol scale without any noticeable loss of yield and stereoselectivity.
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