期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 11, 页码 3198-3201出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02453b
关键词
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资金
- NSFC [21372209]
- Chinese Academy of Sciences
- Ministry of Education [SRFDP 20123402110040]
- China Postdoctoral Science Foundation [2014M560513]
- Excellent Young Scientist Foundation of Anhui Province [2013SQRL003ZD]
A palladium(II)-catalyzed C-H arylation directed by tetrazole, a metabolically stable surrogate for the carboxylic acid group in drug design, has been developed. Excellent mono-/di-selectivity was achieved through adjustment of the protecting site on the tetrazole ring. The synthetic utility of this new transformation was demonstrated in the concise total synthesis of Losartan.
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