期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 5, 页码 1294-1306出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02076f
关键词
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资金
- Institut Universitaire de France (IUF)
- Burgundy region (FABER programme, PARI Action 6, SSTIC 6 Imagerie, instrumentation, chimie et applications biomedicales)
This review outlines examples that illustrate a recent and highly innovative concept in the field of (bio)-molecular sensing, namely the simultaneous multi-analyte detection using reactive luminescent probes that are able to produce an optical signal only in response to multiple (bio) chemical inputs and through covalent chemical reactions with target (bio) analytes. Unlike conventional AND molecular logic gates based on supramolecular photochemical mechanisms, these unusual smart optical (bio) probes are suitable tools to track the rise and fall of a wider range of biologically relevant analytes, in complex media and with higher selectivity. The potential utility of this concept for in vivo molecular imaging and possible solutions to adapt the described luminogenic processes to far-red or NIR emitters are also discussed.
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