期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 22, 页码 6286-6290出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00741k
关键词
-
资金
- National Natural Science Foundation of China [21372058, 21272223]
An alternative stapling strategy is described herein using Fmoc-solid phase peptide synthesis ( SPPS) that employed pre-prepared diaminodiacid building blocks to introduce all-hydrocarbon staples into peptides by on-resin cyclization. Compared to unstapled native peptides, diaminodiacid-based stapled peptides exhibited an increased alpha-helicity ratio and stability toward protease. Moreover, the linkage length was found to affect the bioactivity of the peptides and their ability to inhibit the Wnt pathway. Therefore, the new stapling method provides an alternative way to obtain stapled peptides with tunable linkers of diaminodiacids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据