期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 18, 页码 5235-5242出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00419e
关键词
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资金
- CSIR Innovation Center [ITR-001]
- UGC
- DST
- CSIR [BSC-0205]
A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)-H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(II) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been demonstrated.
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