期刊
JOURNAL OF HUMAN HYPERTENSION
卷 25, 期 6, 页码 354-363出版社
SPRINGERNATURE
DOI: 10.1038/jhh.2010.74
关键词
blood pressure; olmesartan/amlodipine; patient subgroups
资金
- Daiichi Sankyo
- Daiichi Sankyo Europe
Effective antihypertensive therapy is crucial for preventing cardiovascular events; however, blood pressure (BP) control rates remain poor. The objective of this analysis was to determine the efficacy of olmesartan/amlodipine in age, severity and gender-based subgroups of patients with moderate-to-severe hypertension uncontrolled by amlodipine monotherapy. Patients with uncontrolled BP after 8 weeks' amlodipine 5 mg monotherapy (n = 755) were randomized to continue amlodipine 5 mg or receive olmesartan (10-40 mg) plus amlodipine 5 mg for 8 weeks. Patients whose BP remained suboptimal were uptitrated to olmesartan/amlodipine 20/5, 40/5 or 40/10 mg. Changes in BP and numbers of controlled patients were calculated separately to assess efficacy in patients aged < 65 or >= 65 years, in those with moderate or severe hypertension, and in males and females. The antihypertensive effects of olmesartan/amlodipine were similar in patients aged < 65 and >= 65 years of age. Compared with patients with moderate hypertension at baseline, those with severe hypertension tended to show higher decreases in BP, but achieved lower goal rates despite this. Females showed larger mean reductions in diastolic (1.61 mm Hg; P = 0.003) and systolic BP (1.72 mm Hg; P = 0.053) than males, independent of age and dose. This gender difference appeared to be higher and more consistent across dose groups for patients < 50 years of age, but the difference in the pattern between both age groups was not statistically significant (P = 0.1526). These results suggest that olmesartan/amlodipine is effective and safe in a wide range of patients, regardless of age or hypertension severity. Small differences in responsiveness between females and males may exist, which require further investigation. Journal of Human Hypertension (2011) 25, 354-363; doi:10.1038/jhh.2010.74; published online 5 August 2010
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