期刊
JOURNAL OF HUMAN HYPERTENSION
卷 23, 期 8, 页码 556-558出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jhh.2009.19
关键词
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Reduction in expression levels of glutathione S-transferase (GST) mu type 1 (GSTM1) in stroke-prone spontaneously hypertensive rats has recently been reported. GSTM1 genotype was evaluated in 49 patients with resistant hypertension and compared with selected patients with controlled hypertension (n = 232) and healthy participants (n = 110). Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P = 0.03; RR 1.96; 95% CI 1.04-3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.
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