The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with β-blockade

Genetic polymorphisms that influence smooth muscle cell contraction and relaxation may affect the response to anti-hypertensive therapy. Our finding of lower blood pressure in the setting of treatment for hypertension, particularly with beta-blockade, in Caucasian KCNMB1-E65K carriers in two community cohorts has implications for personalization of therapy in hypertension.