期刊
JOURNAL OF HUMAN GENETICS
卷 59, 期 11, 页码 623-629出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jhg.2014.82
关键词
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资金
- Croatian Ministry of Science, Education, and Sports of the Republic of Croatia [108-10803150302, 196-1962766-2747, 196-1962766-2751, 1961962766-2763]
- Medical Research Council UK
Leptin, a possible mediator between energy homeostasis, inflammation and cardiovascular disease (CVD), acts via leptin receptors. We investigated association of single-nucleotide polymorphisms (SNPs) and haplotypes of the leptin receptor gene (LEPR) with several CVD risk factors: body mass index, waist circumference (WC), serum lipids, fibrinogen and C-reactive protein levels. Thirty-one SNPs in and near LEPR gene were analyzed in 986 inhabitants of the island of Vis, Croatia and 29 SNPs in the inland sample (N=499). We assessed linkage disequilibrium (LD), SNP and haplotype associations with the selected phenotypes. rs4291477 significantly associated with fibrinogen (P=0.003) and rs7539471 marginally significantly with high-density lipoprotein (P=0.004), but only in the Vis sample, while rs10493384 marginally significantly associated with triglyceride levels (P=0.006) in the inland sample. SNPs were grouped into eight LD blocks in Vis and in seven blocks in the inland population. Haplotype A-C-A-A-G-A in block 5 in Vis (rs1782754, rs1171269, rs1022981, rs6673324, rs3790426, rs10493380) and haplotype A-A-A-A in block 4 in the inland data (rs1782754, rs1022981, rs6673324, rs1137100) were nominally associated with WC, P=7.085 x 10(-22) (adjusted P=0.0979) and P=5.496 x 10(-144) (adjusted P=0.1062), respectively.
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