期刊
JOURNAL OF HUMAN GENETICS
卷 58, 期 6, 页码 362-365出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jhg.2013.14
关键词
GDM; glycemic trait; GWAS; 1-h plasma glucose; T2D
资金
- Korea Center for Disease Control and Prevention [4845-301, 4851-302, 4851-307]
- Korea National Institute of Health [2012-N73002-00]
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2012R1A2A1A03006155]
- Korea Health Promotion Institute [2012-N73002-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012R1A2A1A03006155] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Most recently, 1-h hyperglycemia has been recognized as an additional risk factor for type 2 diabetes. To date, previous genome-wide association studies for glycemic traits have a limited impact on the fasting state and 2-h plasma glucose level in an oral glucose challenge. To identify genetic susceptibility in different stages of glucose tolerance, we performed a meta-analysis for glycemic traits including 1-h plasma glucose (1-hPG) from 14 232 non-diabetic individuals in the Korean population. Newly implicated variants (MYL2, C12orf51 and OAS1) were found to be significantly associated with 1-hPG. We also demonstrated associations with gestational diabetes mellitus. Our results could provide additional insight into the genetic variation in the clinical range of glycemia.
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