Asymmetric Michael addition of alpha-fluoro-alpha-nitro esters to nitroolefins: towards synthesis of alpha-fluoro-alpha-substituted amino acids

alpha-Fluoro-alpha-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities. Moreover, alpha-fluoro-alpha-amino ester with a quaternary alpha-carbon was prepared for the first time.