期刊
JOURNAL OF HUMAN GENETICS
卷 56, 期 11, 页码 806-809出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jhg.2011.107
关键词
association study; major depressive disorder; neurotrophin; p75(NTR); Ser205Leu polymorphism
资金
- Japan Society for the Promotion of Science
- Health and Labor Sciences Research Grants (Comprehensive Research on Disability, Health and Welfare)
- JST
- CREST
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP
- Grants-in-Aid for Scientific Research [23791371, 20390318] Funding Source: KAKEN
Altered neurotrophin functions have been implicated in major depressive disorder (MDD). Previously, we reported an association between MDD and a missense polymorphism (Ser205Leu: rs2072446) of the gene encoding the p75 neurotrophin receptor (p75(NTR)). However, contradictive negative results have also been reported. This study tried to replicate the association in an independent sample. Subjects were 668 patients with MDD and 1130 healthy controls. The proportion of individuals carrying the Leu205 allele was significantly decreased in the patients than in the controls (chi(2)=5.3, d.f.=1, P=0.021, odds ratio (OR) 0.74, 95% confidential interval (CI) 0.58-0.96). When allele frequencies were compared, the Leu205 allele was significantly reduced in the patients than in the controls (chi(2)= 4.4, d.f.=1, P=0.037, OR=0.78, 95% CI=0.61-0.99). When men and women were examined separately, there was a significant difference in genotype and allele distributions in women (genotype: chi(2)=8.3, d.f.=1, P=0.0039, OR=0.60, 95% CI=0.43-0.85; allele: chi(2)=7.3, d.f.=1, P 0.0069, OR=0.64, 95% CI=0.47-0.89), but not in men. The present study provided support for the previously reported association between the Ser205Leu polymorphism of the p75NTR gene and MDD, indicating that the Leu205 allele has a protective effect against the development of MDD, particularly in women. Journal of Human Genetics (2011) 56, 806-809; doi: 10.1038/jhg.2011.107; published online 22 September 2011
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