期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 15, 页码 4395-4398出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00175g
关键词
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资金
- South University of Science and Technology of China (SUSTC)
- National Natural Science Foundation of China [NSFC 21302089]
An organocatalytic asymmetric Friedel-Crafts reaction between indole and indole-derived hydroxylactams has been realized to furnish isoindolo-beta-carbolines in good to excellent yields (up to >99%) and generally high enantioselectivities (up to >99% ee). The methodology offers an efficient access to functionalization of isoindolo-beta-carbolines and preparation of chiral isoindolo-beta-carboline derivatives.
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