期刊
JOURNAL OF HUMAN GENETICS
卷 54, 期 5, 页码 298-303出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jhg.2009.29
关键词
cyclin-dependent kinase 5 (CDK5); lung cancer; single-nucleotide polymorphism
资金
- Ministry of Health & Welfare, Republic of Korea [A010250]
- Korea Health Promotion Institute [A010250] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. For example, a recent study detected overexpression of the CDK5 gene in non-small-cell lung cancer. Therefore, in order to explore the association of the CDK5 gene with lung cancer risk in a Korean population, the genotypes of the CDK5 promoter region were determined in 407 lung cancer patients and 402 normal participants. The result showed that the -904 G>A genotype affected susceptibility to lung cancer risk (odd ratios (OR)=1.53, 95% confidence interval (CI)=1.02-2.32). Furthermore, subsequent haplotype analysis of three single-nucleotide polymorphism (SNP) regions suggested that the A-G-C haplotype was associated with a higher overall risk of lung cancer (OR=1.59, 95% CI=1.16-2.18). These results suggest that CDK5 promoter polymorphisms contribute to the genetic susceptibility to lung cancer in the Korean population. Journal of Human Genetics (2009) 54, 298-303; doi:10.1038/jhg.2009.29; published online 3 April 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据