期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 11, 页码 3227-3235出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02567a
关键词
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资金
- National Natural Science Foundation of China [21277091]
- State key Program of National Nature Science Foundation of China [21436007]
- Key Basic Research Projects of Science and Technology Commission of Shanghai [14JC1403100]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [ZXDF160002]
- SRF for ROCS, SEM [BG1600002]
A novel and efficient strategy for one-step synthesis of allylated quinolines and isoquinolines via palladium-catalyzed cyclization-allylation of azides and allyl methyl carbonate is developed for the first time. The results indicated that the regioselective synthesis of allyl-and diallyl-substituted quinolines/isoquinolines depends on different substituted groups at R-1 and R-4 positions, such as H or other groups. The reactions proceed smoothly in the presence of Pd(PPh3)(4) and K3PO4 or NaOAc in DMF at 100 degrees C to give the corresponding allyl-and diallyl-substituted quinolines and isoquinolines in good to high yields.
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