期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 4, 页码 1030-1039出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02185a
关键词
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资金
- Fonds der Chemischen Industrie
- Nordrhein-Westfalische Akademie der Wissenschaften und der Kunste [PCIG10-GA-2011-303872]
- COST Action [CM1005]
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character. By establishing state diagrams we describe their pH and ionic strength triggered self-assembly into supramolecular nanorods in water and highlight the impact of hydrophobic shielding in the supramolecular polymerisation process. Via the incorporation of fluorinated peptide side chains the pH-triggered monomer to polymer transition at physiological ionic strength is shifted from pH 5.0 to pH 7.4. We thereby show that compensating attractive non-covalent interactions and hydrophobic effects with repulsive electrostatic forces, a concept we refer to as frustrated growth, is a sensitive tool in order to manipulate one-dimensional supramolecular polymerisation processes in water.
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