期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 1, 页码 77-80出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02155j
关键词
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资金
- FP7 EU grant (METOXIA)
- FP7 EU grant (DYNANO)
A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms. All the compounds showed excellent selectivity against the mitochondrial (hCA VA) and the tumor associated (hCA IX and XII) enzymes.
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