期刊
JOURNAL OF HOSPITAL INFECTION
卷 75, 期 1, 页码 37-41出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2010.01.012
关键词
Acinetobacter baumannii; Epidemiology; Multidrug resistance; Single nucleotide polymorphism; Whole-genome sequencing; 454 pyrosequencing
资金
- Hospital Infection Society, London, UK
- BBSRC [BBE0111791]
Shared care of military and civilian patients has resulted in transmission of multidrug-resistant Acinetobacter baumannii (MDR-Aci) from military casualties to civilians. Current typing technologies have been useful in revealing relationships between isolates of A. baumannii but they are unable to resolve differences between closely related isolates from small-scale outbreaks, where chains of transmission are often unclear. In a recent hospital outbreak in Birmingham, six patients were colonised with MDR-Aci isolates indistinguishable using standard techniques. We used whole-genome sequencing to identify single nucleotide polymorphisms in these isolates, allowing us to discriminate between alternative epidemiological hypotheses in this setting. (C) 2010 Published by Elsevier Ltd on behalf of The Hospital Infection Society.
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