期刊
JOURNAL OF HISTOTECHNOLOGY
卷 41, 期 4, 页码 160-176出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01478885.2018.1505205
关键词
Bone marrow mesenchymal stem cells; crush injuries; exosome; sciatic nerve
类别
资金
- Benha University
The aim was to evaluate the potential effect of bone marrow-derived mesenchymal stem cells (BMSC) and BMSC-EX in the sciatic nerve injury. Forty-five rats were divided into four groups, i.e. Group I control no surgery or treatment, Group II sciatic nerve crush surgery and 1 week post-surgery, Group III sciatic nerve crush injury was treated with BMSC, and Group IV sciatic nerve crush injury was treated with BMSC-EX. All animal groups were euthanized 2 weeks after treatment. Sciatic nerves were examined histologically and immunohistochemically. Group H showed various histological changes, i.e. vacuolation, degeneration and loss of nerve fibers. Group II showed a significant increase in collagen fibers, but with significant reduction in osmium tetroxide (OsO4)-stained myelin sheaths and neurofilament immunostaining compared to Group I. Group II also revealed distortion and disruption of myelinated nerve fibers. Groups III and IV showed significant improvement of both histological and immunohistochemical changes in Group II. BMSC and BMSC-EX were shown to improve axonal regeneration.
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