期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 62, 期 3, 页码 172-184出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155413517701
关键词
Kinase; Microfilaments; Proteoglycan; Cytoskeleton; Adhesion
类别
资金
- Danish National Research Foundation
- Lundbeck Fonden
- Novo Nordisk Fonden
- department of Biomedical Sciences at the University of Copenhagen
Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.
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