期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 59, 期 1, 页码 106-115出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.2010.956961
关键词
colorectal carcinoma; REG; pathobiological behavior; prognosis
类别
资金
- Shenyang Outstanding Talent Foundation of China
- Shenyang Science and Technology Grant [1091175-1-00]
- Liaoning BaiQianWan Talents Program
- Scientific and Technological Projects for Overseas Returned Persons, Ministry of Personnel
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- Natural Scientific Foundation of China [81001093]
- Ministry of Education, Culture, Sports and Technology of Japan [20659109, 21790624]
- Japanese Smoking Research Foundation
- Japanese Uehara Memorial Foundation
Regenerating (REG) gene family belongs to the calcium-dependent lectin gene superfamily and encodes small multifunctional secretory proteins, which might be involved in cell proliferation, differentiation, and carcinogenesis. To clarify REG expression profile in colorectal carcinoma (CRC), the authors examined the expression of REG I alpha, I beta, III, HIP/PAP, and REG IV by immunohistochemistry on tissue microarray. The expression of REG I alpha, III, and HIP/PAP was more frequently observed in the CRCs than adjacent non-neoplastic mucosa (p < 0.001), whereas it was the converse for REG I beta and IV (p < 0.001). The expression of REG I alpha, I beta, III, and HIP/PAP was negatively correlated with the depth of invasion of CRCs (p < 0.05). The REG I beta and HIP/ PAP were less expressed in CRCs with than without venous invasion (p < 0.05). The positive rates of REG I alpha and HIP/ PAP were significantly higher in CRCs without than with lymph node metastasis (p < 0.05). Mucinous carcinoma more frequently expressed REG IV protein than well-and moderately differentiated ones (p < 0.05). There was a positive relationship between REG I alpha, I beta, III, and HIP/ PAP expression (p < 0.05). Survival analysis indicated the REG I beta or HIP/ PAP expression was positively linked to favorable prognosis of carcinoma patients (p < 0.05). This study indicated that aberrant REG expression might be closely linked to the pathogenesis, invasion, or lymph node metastasis of CRCs. REG I beta and HIP/ PAP could be considered reliable markers of favorable prognosis of CRC patients. (J Histochem Cytochem 59:106-115, 2011)
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