期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 58, 期 11, 页码 941-955出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.2010.956201
关键词
stem cells; human satellite cells; mouse satellite cells; skeletal muscle regeneration
类别
资金
- Muscular Dystrophy Campaign
- Wellcome Trust University
- MRC [G0601943] Funding Source: UKRI
- Medical Research Council [G0601943] Funding Source: researchfish
Satellite cells are quiescent cells located under the basal lamina of skeletal muscle fibers that contribute to muscle growth, maintenance, repair, and regeneration. Mouse satellite cells have been shown to be muscle stem cells that are able to regenerate muscle fibers and self-renew. As human skeletal muscle is also able to regenerate following injury, we assume that the human satellite cell is, like its murine equivalent, a muscle stem cell. In this review, we compare human and mouse satellite cells and highlight their similarities and differences. We discuss gaps in our knowledge of human satellite cells, compared with that of mouse satellite cells, and suggest ways in which we may advance studies on human satellite cells, particularly by finding new markers and attempting to re-create the human satellite cell niche in vitro. (J Histochem Cytochem 58:941-955, 2010)
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