Studies on Synthesis and Biological Activity of Oxidative Aglafolin Derivatives

The synthesis of the key intermediate of rocaglamide, oxidative aglafolin, was studied, and its diastereoisomers were obtained. The amination of oxidative aglafolin was also investigated, affording amino derivatives. The preliminary bioassay results indicate that these new aglafolin derivatives showed certain degree of insecticidal and repellent activity against Plutella xylostella and Laphygma exigua.