A convenient synthesis of novel functionalized 1,4-dimethylcarbazole derivatives containing 3,4,5-trimethoxybenzamido-ureido or N-(3,4,5-trimethoxyphenyl)ureido group starting from their corresponding indole derivatives is reported. Three derivatives prepared (5g, 6c, and 6g) were active against leukemia cell lines HL60. Both 5g and 6g showed potent antiproliferative activity against KB cell lines, likely associated with the inhibition of tubulin polymerization.
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