期刊
JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 52, 期 5, 页码 1302-1307出版社
WILEY
DOI: 10.1002/jhet.2230
关键词
multi-component reaction; microwave method; classical method; 1; 4-dihydro quinolines
An atom-efficient, catalyst-free, and environmentally friendly approach towards the synthesis of substituted 1,4-dihydroquinolines (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j) through a one-pot multicomponent reaction involving resorcinol, aromatic aldehyde, acetoacetanilide, and ammonium acetate has been developed. The reactions were carried out under both conventional and microwave irradiation conditions. In general, improvement in rate and yield were observed when reactions were carried out under microwave irradiation compared with classical conditions. Most of the new compounds possessed moderate to significant antibacterial and antifungal activities.
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