Green Approach to the Design of Functionalized Medicinally Privileged 4-Aryl-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile Scaffold

On water multicomponent condensation of aromatic aldehydes, malononitrile, and 3-methyl-2-pyrazoline-5-one in the presence of sodium hydroxide as catalyst leads to 6-amino-3-methyl-4-aryl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in 85-98% yields.