Ionic Liquid Promoted Multicomponent Reaction: A Good Strategy for the Eco-Compatible Synthesis of Functionalized Pyrroles

Task specific [bmim]BF4 was found to be reusable, alternative, and effective reaction media for multicomponent synthesis of highly functionalized pyrroles. Generality of the procedure was established by synthesizing various pyrroles from wide range of aromatic/aliphatic amine, phenacyl bromide, and electrophilic alkynes by utilizing this protocol without any acid or metal catalyst. Ecocompatibility, short reaction time, excellent yield, recyclability of [bmim]BF4, low cost, easy work-up, and mild reaction conditions are additional advantages of the procedure in the context of sustainable and green chemistry.