期刊
JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 50, 期 -, 页码 E87-E92出版社
WILEY
DOI: 10.1002/jhet.1072
关键词
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资金
- Fondazione Banco di Sardegna
In this study, the authors have designed and synthesized a novel series of 3-acyl-4-aryl-4,5-dihydropyrazoles, with the aim to obtain new potential scaffolds for the inhibition of both isoforms of monoamine oxidase (MAO) enzyme. The synthetic pathway to these compounds includes as a key step the 1,3-dipolar cycloaddition reaction of diazomethane with a chalcone. All the compounds were fully characterized by means of spectroscopic and analytical data and showed specific inhibition against MAO A.
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